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KMID : 0604520130390020127
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 2 p.127 ~ p.132
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Whitening Effects of Adamantyl Benzamide Derivatives
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Baek Heung-Soo
Ahn Soo-Mi
Woo Byoung-Young
Cho Young-Seok
Choi Soo-Jeong
Rho Ho-Sik
Byoun Kyoung-Hee
Shin Song-Seok
Park Young-Ho
Joo Yung-Hyup
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Abstract
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The structure activity relationship of polyhydroxylated benzamide derivatives for whitening effects was examined. The adamantyl benzamide derivatives with catechol (3,4-dihydroxyphenyl) of B-ring part showed good anti- melanogenesis activity, but the inhibitory activity of mono-hydroxyphenyl (3-OH or 4-OH) or 3,4-dimethoxyphenyl substituted derivatives was decreased or lost. Therefore the catechol unit was appeared to be the crucial factor for the inhibition of melanogenesis. And the existence of 2-OH of A-ring part had minor influence on the activity, the length of carbon chain between A-ring and B-ring was also not the major factor for the anti-melanogenesis activity.
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KEYWORD
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melanogenesis, adamantyl N-benzylbenzamide, adamantyl N-phenethylbenzamide, polyhydroxypropanoid, tyrosinase
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